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Recombinant Human CD20 protein (ab158047)

Key features and details

  • Expression system: Wheat germ
  • Purity: > 80% n/a
  • Tags: GST tag N-Terminus
  • Suitable for: ELISA, WB

Description

  • Product name

    Recombinant Human CD20 protein
    See all CD20 proteins and peptides

  • Purity

    > 80 % n/a.
    Glutathione Sepharose 4 Fast Flow

  • Expression system

    Wheat germ

  • Accession

    931

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MTTPRNSVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESK TLGAVQIMNGLFHIALGGLLMIPAGIYAPICVTVWYPLWGGIMYIISGSL LAATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMDILNIKISHFLKME SLNFIRAHTPYINIYNCEPANPSEKNSPSTQYCYSIQSLFLGILSVMLIF AFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQTIEIKEEVVGLT ETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQESSPIENDSSP

    • Predicted molecular weight

      58 kDa

    • Amino acids

      1 to 297

    • Tags

      GST tag N-Terminus

Preparation and Storage

  • Alternative names

    • APY
    • ATOPY
    • B lymphocyte antigen CD20
    • B Lymphocyte Cell Surface Antigen B1
    • B-lymphocyte antigen CD20
    • B-lymphocyte cell-surface antigen B1
    • B-lymphocyte surface antigen B1
    • B1
    • Bp 35
    • Bp35
    • CD 20
    • CD20
    • CD20 antigen
    • CD20 receptor
    • CD20_HUMAN
    • CVID 5
    • CVID5
    • Fc epsilon receptor I beta chain
    • Fc Fragment of IgE high affinity I receptor for beta polypeptide
    • FCER1B
    • High affinity immunoglobulin epsilon receptor subunit beta
    • IgE Fc receptor subunit beta
    • IGEL
    • IGER
    • IGHER
    • LEU 16
    • Leu-16
    • LEU16
    • leukocyte surface antigen Leu 16
    • Leukocyte surface antigen Leu-16
    • Ly44
    • Membrane spanning 4 domains A1
    • Membrane spanning 4 domains subfamily A member 2
    • membrane-spanning 4-domains A1
    • Membrane-spanning 4-domains subfamily A member 1
    • MGC3969
    • MS4A1
    • MS4A2
    • S7
    see all

  • Function

    This protein may be involved in the regulation of B-cell activation and proliferation.

  • Tissue specificity

    Expressed on B-cells.

  • Involvement in disease

    Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.

  • Sequence similarities

    Belongs to the MS4A family.

  • Post-translational
    modifications

    Phosphorylated. Might be functionally regulated by protein kinase(s).

  • Cellular localization

    Membrane.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human CD20 protein (ab158047)
    SDS-PAGE - Recombinant Human CD20 protein (ab158047)
    ab158047 on a 12.5% SDS-PAGE stained with Coomassie Blue.

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