Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant human BMP7 protein (Active) (ab245953)

Key features and details

  • Expression system: CHO cells
  • Endotoxin level:
  • Active: Yes
  • Suitable for: SDS-PAGE, Functional Studies, HPLC

Description

  • Product name

    Recombinant human BMP7 protein (Active)
    See all BMP7 proteins and peptides

  • Biological activity

    Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.02-0.04 μg/ml.

  • Endotoxin level

  • Expression system

    CHO cells

  • Accession

    P18075

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MANVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECA FPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSN VILKKYRNMVVRACGCH

    • Predicted molecular weight

      26 kDa

    • Amino acids

      315 to 431

    • Associated products

      Specifications

      Our Abpromise guarantee covers the use of ab245953 in the following tested applications.

      The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

      • Applications

        SDS-PAGE

        Functional Studies

        HPLC

      • Form

        Lyophilized

      • Additional notes

        Migrates at an apparent molecular weight of approximately 25-35 kDa by SDS-PAGE analysis under non-reducing conditions.

      • Concentration information loading...

      Preparation and Storage

      • Stability and Storage

        Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

        This product is an active protein and may elicit a biological response in vivo, handle with caution.

      • Reconstitution
        Reconstitute in water to 0.1 - 1.0 mg/ml.

      General Info

      • Alternative names

        • BMP 7
        • BMP-7
        • Bmp7
        • BMP7_HUMAN
        • Bone morphogenetic protein 7
        • Bone morphogenic protein 7
        • Eptotermin alfa
        • OP 1
        • OP-1
        • OP1
        • Osteogenic protein 1
        see all

      • Function

        Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.

      • Tissue specificity

        Expressed in the kidney and bladder. Lower levels seen in the brain.

      • Sequence similarities

        Belongs to the TGF-beta family.

      • Developmental stage

        Expressed in the developing eye, brain and ear during embryogenesis.

      • Post-translational
        modifications

        Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms (PubMed:17977014).

      • Cellular localization

        Secreted.
      • Information by UniProt

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (0)

    Publishing research using ab245953? Please let us know so that we can cite the reference in this datasheet.

    ab245953 has not yet been referenced specifically in any publications.

    Preparation and Storage

    • Alternative names

      • BMP 7
      • BMP-7
      • Bmp7
      • BMP7_HUMAN
      • Bone morphogenetic protein 7
      • Bone morphogenic protein 7
      • Eptotermin alfa
      • OP 1
      • OP-1
      • OP1
      • Osteogenic protein 1
      see all

    • Function

      Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.

    • Tissue specificity

      Expressed in the kidney and bladder. Lower levels seen in the brain.

    • Sequence similarities

      Belongs to the TGF-beta family.

    • Developmental stage

      Expressed in the developing eye, brain and ear during embryogenesis.

    • Post-translational
      modifications

      Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms (PubMed:17977014).

    • Cellular localization

      Secreted.
    • Information by UniProt

    Images

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

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