Recombinant HIV gp41 L protein (ab49071)
Key features and details
- Expression system: Escherichia coli
- Suitable for: ELISA, WB
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Product name
Recombinant HIV gp41 L protein
See all HIV gp41 L proteins and peptides -
Expression system
Escherichia coli -
Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant
Preparation and Storage
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Alternative names
- env
- Glycoprotein 41
- gp41
see all -
Relevance
The transmembrane protein gp41 (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm. -
Cellular localization
Cell membrane
