Antibodies, Proteins, Kits and Reagents for Life Science

Recombinant Cyclophilin B protein (ab53870)

Key features and details

Expression system: Escherichia coli
Purity: > 95% SDS-PAGE
Endotoxin level:
Active: Yes
Suitable for: SDS-PAGE, Functional Studies

Alternative names
- AA408962
- AA553318
- AI844835
- Cphn 2
- Cphn2
- Cyclophilin B
- Cyclophilin like protein
- CyP 20b
- CYP S1
- CYP-S1
- CYPB
- EC 5.2.1.8
- MGC14109
- MGC2224
- OI9
- peptidyl prolyl cis trans isomerase B
- Peptidyl prolyl cis trans isomerase B precursor
- Peptidyl-prolyl cis-trans isomerase B
- Peptidylprolyl isomerase B
- peptidylprolyl isomerase B (cyclophilin B)
- PPIase
- PPIase B
- Ppib
- PPIB_HUMAN
- Rotamase
- Rotamase B
- S cyclophilin
- S-cyclophilin
- SCYLP
see all
Function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Involvement in disease

Defects in PPIB are the cause of osteogenesis imperfecta type 9 (OI9) [MIM:259440]. OI9 is a connective tissue disorder characterized by bone fragility, low bone mass and bowing of limbs due to multiple fractures. Short limb dwarfism and blue sclerae are observed in some but not all patients.
Sequence similarities

Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.
Contains 1 PPIase cyclophilin-type domain.
Cellular localization

Endoplasmic reticulum lumen. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Target information above from: UniProt accession P23284 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

SDS-PAGE - Recombinant Cyclophilin B protein (ab53870)

ab53870 on 15% SDS-PAGE (3μg)

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