Rebeccamycin, Antibiotic agent (ab144341)
Key features and details
- Antibiotic agent. Weak topoisomerase I inhibitor. Potent antiproliferative agent.
- CAS Number: 93908-02-2
- Purity: > 98%
- Soluble in DMSO to 5 mM
- Form / State: Solid
- Source: Streptomyces sp.
Overview
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Product name
Rebeccamycin, Antibiotic agent -
Description
Antibiotic agent. Weak topoisomerase I inhibitor. Potent antiproliferative agent. -
Biological description
Antibiotic agent. Weak, selective topoisomerase I inhibitor. Potent antiproliferative agent (IC50 values are 100, 200, 300, 480 and 500 nM for L1210, K562, A549, B16 melanoma and P388 leukemia cells respectively). Does not show any inhibitory activity against protein kinases. -
Purity
> 98% -
CAS Number
93908-02-2 -
Chemical structure
Properties
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Chemical name
1,11-Dichloro-12-(4-O-methyl-β-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione -
Molecular weight
570.38 -
Molecular formula
C27H21Cl2N3O7 -
PubChem identifier
73110 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 5 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CO[C@@H]1[C@H](O[C@H]([C@@H]([C@H]1O)O)N2C3=C(C=CC=C3Cl)C4=C5C(=C6C7=C(C(=CC=C7)Cl)NC6=C42)C(=O)NC5=O)CO -
Source
Streptomyces sp.
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Research areas
