R 7050 (ab273389)
Key features and details
- Cell permeable TNF-α receptor signaling antagonist
- CAS Number: 303997-35-5
- Purity: > 99%
Soluble in dimethyl formamide to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
R 7050 -
Description
Cell permeable TNF-α receptor signaling antagonist -
Biological description
Cell-permeable TNF-α receptor signaling antagonist (EC50 = 0.631 μM in ICAM-1 ELISA assay). Blocks TNFR1 association with TRADD and RIP1. Blocks TNF-α -induced activation of NF-κB and MAPK pathway signaling. Blocks nuclear translocation of NF-κB. Selective for (2.3-fold) for TNF-α-mediated signaling over IL-1β- mediated signaling. Protects against neovascular injury in animal models of intracerebral hemorrhage.
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Purity
> 99% -
CAS Number
303997-35-5 -
Chemical structure
Properties
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Chemical name
8-Chloro-4-(phenylthio)-1-(trifluoromethyl)[1,2,4]triazolo[4,3-a]quinoxaline
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Molecular weight
380.80 -
Molecular formula
C16H8ClF3N4S -
PubChem identifier
1486608 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in dimethyl formamide to 25 mM
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Handling
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC=C(C=C1)SC2=NC3=C(C=C(C=C3)Cl)N4C2=NN=C4C(F)(F)F -
Source
Synthetic
Images
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Chemical Structure - R 7050 (ab273389)
Chemical structure of R 7050, 303997-35-5