Pyrimidyn-7™, dynamin inhibitor (ab144501)
Key features and details
- Novel, potent dual action dynamin inhibitor
- CAS Number: 1440126-94-2
- Purity: > 97%
- Supplied in DMSO (50 mM)
- Form / State: Liquid
- Source: Synthetic
Overview
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Product name
Pyrimidyn-7™, dynamin inhibitor -
Description
Novel, potent dual action dynamin inhibitor -
Biological description
Novel, potent dual action dynamin inhibitor (IC50 values are 1.1 and 1.8 µM at dynamin I and II respectively). Only inhibitor to target two distinct domains of dynamin.
Competitively inhibits both GTP and phospholipid binding. Reversibly inhibits clathrin mediated endocytosis (CME) and synaptic vesicle endocytosis (SVE) in nerve terminals. -
Purity
> 97% -
General notes
Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. Pyrimidyn™ is a trademark of Children's Medical Research Institute and Newcastle Innovation Ltd -
CAS Number
1440126-94-2 -
Chemical structure
Properties
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Chemical name
N2-[2-(Dimethylamino)ethyl]-N4-dodecyl-6-methyl-2,4-pyrimidinediamine -
Molecular weight
363.59 -
Molecular formula
C21H41N5 -
Storage instructions
Store at -20°C (desiccating conditions). -
Solubility overview
Supplied in DMSO (50 mM) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN(C)CCNc1nc(C)cc(NCCCCCCCCCCCC)n1 -
Source
Synthetic
