PS48, Allosteric phosphoinositide-dependent protein kinase-1 (PDK1) agonist (ab142133)
Key features and details
- Allosteric phosphoinositide-dependent protein kinase-1 (PDK1) agonist
- CAS Number: 1180678-32-7
- Purity: > 95%
- Soluble in DMSO to 100 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
PS48, Allosteric phosphoinositide-dependent protein kinase-1 (PDK1) agonist -
Description
Allosteric phosphoinositide-dependent protein kinase-1 (PDK1) agonist -
Biological description
Allosteric PDK1 activator. Stimulates PI3-kinase and phosphorylates AKT. Binds to the PIF pocket in the small lobe of PDK1. Shows developmental effects in vivo. -
Purity
> 95% -
CAS Number
1180678-32-7 -
Chemical structure
Properties
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Chemical name
(Z)-5-(4-Chlorophenyl)-3-phenylpent-2-enoic acid -
Molecular weight
286.75 -
Molecular formula
C17H15ClO2 -
PubChem identifier
44141940 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC=C(C=C1)C(=CC(=O)O)CCC2=CC=C(C=C2)Cl -
Source
Synthetic
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Research areas
