Prostaglandin J2, PGD2 analog (ab120913)
Key features and details
- Endogenous product of inflammation; PGD2 analog
- CAS Number: 60203-57-8
- Purity: > 95%
- Supplied in methyl acetate (5 mg/ml)
- Form / State: Liquid
- Source: Synthetic
Overview
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Product name
Prostaglandin J2, PGD2 analog -
Description
Endogenous product of inflammation; PGD2 analog -
Alternative names
- PGJ2
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Biological description
Endogenous highly reactive product of inflammation. PGD2 analog. Potent neurotoxin and activator of PPARα and PPARγ. Able to trigger pro-apoptotic responses in neuronal cells. -
Purity
> 95% -
CAS Number
60203-57-8 -
Chemical structure
Properties
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Chemical name
(5Z,13E,15S)-15-Hydroxy-11-oxoprosta-5,9,13-trien-1-oic acid -
Molecular weight
334.45 -
Molecular formula
C20H30O4 -
Storage instructions
Store at -80°C. -
Solubility overview
Supplied in methyl acetate (5 mg/ml) -
Handling
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCCCCC(O)/C=C/[C@@H]1C(C/C=CCCCC(=O)O)C=CC1=O -
Source
Synthetic
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Research areas
Images
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Functional Studies - Prostaglandin J2, PGD2 analog (ab120913)ab80579 staining tau in SKNSH cells treated with prostaglandin J2 (ab120913), by ICC/IF. Expression of tau expression is restringed to the perinuclear zone with increased concentration of prostaglandin J2, as described in literature.
The cells were incubated at 37°C for 6 hours in media containing different concentrations of ab120913 (prostaglandin J2) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab80579 (10 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei (blue) were counterstained with DAPI and membrane is was stained using WGA (red).