Plumbagin, Anticancer and anti-inflammatory agent (ab145184)
Key features and details
- Anticancer and anti-inflammatory agent
- CAS Number: 481-42-5
- Soluble in ethanol to 50 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Plumbago indica
Overview
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Product name
Plumbagin, Anticancer and anti-inflammatory agent -
Description
Anticancer and anti-inflammatory agent -
Biological description
Anticancer and anti-inflammatory agent. Promotes autophagocytosis. Induces G2/M cell cycle arrest and apoptosis. Inhibits Akt/mTOR signaling. Induces PI 5 kinase-dependent- ROS generation. Inhibits NFκB activation. Shows antitumor and immunosuppressive effects in vivo. -
CAS Number
481-42-5 -
Chemical structure
Properties
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Chemical name
5-Hydroxy-2-methylnaphthalene-1,4-dione -
Molecular weight
188.18 -
Molecular formula
C11H8O3 -
PubChem identifier
10205 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 50 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=CC(=O)C2=C(C1=O)C=CC=C2O -
Source
Plumbago indica
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Research areas