PIK 75 hydrochloride, p110alpha PI3K inhibitor (ab120931)
Key features and details
- Selective p110α PI3K inhibitor
- CAS Number: 372196-77-5
- Purity: > 98%
- Soluble in DMSO to 5 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
PIK 75 hydrochloride, p110alpha PI3K inhibitor -
Description
Selective p110α PI3K inhibitor -
Biological description
Selective inhibitor of p110α (IC50 values are 5.8, 76 nM and 1.3 μM at p110α, p110γ and p110β, respectively). Inhibits production of PIP2 and PIP3 in adipocytes, phosphorylation of Akt and activation of mTORC1. Cell-permeable. -
Purity
> 98% -
CAS Number
372196-77-5 -
Chemical structure
Properties
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Chemical name
2-Methyl-5-nitrobenzenesulfonic acid 2-[(6-bromoimidazo[1,2-a]pyridin-3-yl)methylene]-1-methylhydrazide hydrochloride -
Molecular weight
488.74 -
Molecular formula
C16H14BrN5O4S.HCl -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 5 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
BrC1=CN2C(C=C1)=NC(/C=N/N(S(C3=CC([N+]([O-])=O)=CC=C3C)(=O)=O)C)=C2 -
Source
Synthetic
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Research areas