PF-573228 (ab273523)
Key features and details
- Potent and selective FAK inhibitor
- CAS Number: 869288-64-2
- Purity: >= 98%
Soluble in DMSO to 75 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
PF-573228 -
Description
Potent and selective FAK inhibitor -
Biological description
Potent and selective FAK inhibitor (IC50 = 4 nM versus recombunant catalytic fragent). Blocks FAK Tyr397 phosphorylation in cultured cells (IC50 = 30–100 nM). Shows 50 - 250-fold selectivity for FAK aginst a panel of 40 recombinant kinases. Inhibits chemotactic and haptotactic cell migration.
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Purity
>= 98% -
General notes
Protect from air.
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CAS Number
869288-64-2 -
Chemical structure
Properties
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Chemical name
3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5- (trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone
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Molecular weight
491.49 -
Molecular formula
C22H20F3N5O3S -
PubChem identifier
11612883 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store In the Dark. -
Solubility overview
Soluble in DMSO to 75 mM
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Handling
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CS(=O)(=O)C1=CC=CC(=C1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)CC4 -
Source
Synthetic
Images
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Chemical Structure - PF-573228 (ab273523)
Chemical structure of PF-573228, 869288-64-2