PD 174265, EGFR tyrosine kinase inhibitor (ab145146)
Key features and details
- Potent, selective, reversible EGFR tyrosine kinase inhibitor
- CAS Number: 216163-53-0
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
PD 174265, EGFR tyrosine kinase inhibitor -
Description
Potent, selective, reversible EGFR tyrosine kinase inhibitor -
Biological description
Potent, selective, reversible EGFR tyrosine kinase inhibitor (IC50 = 0.45 nM). Antitumor agent. Cell permeable. Active in vivo and in vitro.
See similar compounds -
Purity
> 98% -
CAS Number
216163-53-0 -
Chemical structure
Properties
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Chemical name
N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]propanamide -
Molecular weight
371.24 -
Molecular formula
C17H15BrN4O -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCC(=O)Nc1ccc2c(c1)c(ncn2)Nc1cccc(c1)Br -
Source
Synthetic
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Research areas