PD 158780, ErbB receptor tyrosine kinase inhibitor (ab141267)
Key features and details
- Potent ErbB receptor tyrosine kinase inhibitor
- CAS Number: 171179-06-9
- Purity: > 99%
- Soluble in DMSO to 50 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
PD 158780, ErbB receptor tyrosine kinase inhibitor -
Description
Potent ErbB receptor tyrosine kinase inhibitor -
Biological description
Potent ErbB receptor tyrosine kinase inhibitor (IC50 values are 8 μM, 49 and 52 nM for EGFR, ErbB2 and ErbB2/ErbB4 respectively). Does not inhibit FGF or PDGF-mediated tyrosine phosphorylation. Induces G1 cell cycle arrest and shows antiproliferative effects in vitro. Active in vivo. Centrally active.
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Purity
> 99% -
CAS Number
171179-06-9 -
Chemical structure
Properties
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Chemical name
N4-(3-Bromophenyl)-N6-methylpyrido[3,4-d]pyrimidine-4,6-diamine -
Molecular weight
330.19 -
Molecular formula
C14H12BrN5 -
PubChem identifier
4707 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM and in ethanol to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Brc1cccc(c1)Nc3ncnc2cnc(cc23)NC -
Source
Synthetic
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Research areas
