P 22077 (ab273383)
Key features and details
- Selective USP7 inhibitor
- CAS Number: 1247819-59-5
- Purity: > 98%
Soluble in DMSO to 75 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
P 22077 -
Description
Selective USP7 inhibitor -
Biological description
Selective USP7 (IC50 = 8 μM) inhibitor. Active against closely related USP47. Selective versus SENP2c0re (IC50 >50 μM) and DENI (IC50 >50 μM). Destabilizes Claspin. Inhibits neuroblastoma growth by inducing p53-mediated apoptosis. Inhibits Tip60 deubiquitination.
-
Purity
> 98% -
CAS Number
1247819-59-5 -
Chemical structure
Properties
-
Chemical name
1-[5-[(2,4-Difluorophenyl)thio]-4-nitro-2-thienyl]ethanone
-
Molecular weight
315.32 -
Molecular formula
C12H7F2NO3S2 -
PubChem identifier
46931953 -
Storage instructions
Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 75 mM
-
Handling
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
CC(=O)C1=CC(=C(S1)SC2=C(C=C(C=C2)F)F)[N+](=O)[O-] -
Source
Synthetic
Images
-
Chemical Structure - P 22077 (ab273383)
Chemical structure of P 22077, 1247819-59-5
