OSI-027 (ab273522)
Key features and details
- Potent mTOR inhibitor
- CAS Number: 936890-98-1
- Purity: >= 98%
Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
OSI-027 -
Description
Potent mTOR inhibitor -
Biological description
Potent, ATP-competitive mTOR kinase inhibitor. Inhibits TORC1 (IC50 = 22 nM) and TORC2 (IC50 = 65 nM) mTor complexes. Greater than 100-fold selective for mTOR versus PI3K-alpha, PI3K-beta, PI3K-gamma and DNA-PK. Anti-proliferative against myeloid/megakaryocytic acute lukemia cell lines.
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Purity
>= 98% -
CAS Number
936890-98-1 -
Chemical structure
Properties
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Chemical name
trans-4-[4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7- yl]cyclohexanecarboxylic acid
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Molecular weight
406.45 -
Molecular formula
C21H22N6O3 -
PubChem identifier
135398516 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 25 mM
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Handling
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC1=CC=CC2=C1NC(=C2)C3=C4C(=NC=NN4C(=N3)C5CCC(CC5)C(=O)O)N -
Source
Synthetic
Images
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Chemical Structure - OSI-027 (ab273522)
Chemical structure of OSI-027, 936890-98-1