Olanzapine, 5-HT, dopamine, histamine and muscarinic antagonist (ab120736)
Key features and details
- Non-selective 5-HT, dopamine, histamine and muscarinic antagonist
- CAS Number: 132539-06-1
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
Olanzapine, 5-HT, dopamine, histamine and muscarinic antagonist -
Description
Non-selective 5-HT, dopamine, histamine and muscarinic antagonist -
Biological description
5-HT and D2 antagonist (Ki values are 4 (5-HT2A), 11 (5-HT2C) and 57 (5-HT3), 31 (D1), 11 (D2) and 27 nM (D4)). Additionally, displays activity at: M1, M2, M3, M4, H1, α1 and α2 receptors (Ki are 1.9 at (M1), 18 (M2), 25 (M3), 13 (M4), 19 (α1) and 7 nM (α2)). Atypical antipsychotic. Displays anxiolytic activity.
-
Purity
> 99% -
CAS Number
132539-06-1 -
Chemical structure
Images
-
Functional Studies - Olanzapine, 5-HT, dopamine, histamine and muscarinic antagonist (ab120736)ab32572 staining β catenin in SKNSH cells treated with olanzapine (ab120736), by ICC/IF. Increase in expression of β catenin correlates with increased concentration of olanzapine, as described in literature.
The cells were incubated at 37°C for 24h in media containing different concentrations of ab120736 (olanzapine) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab32572 (1/200 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.