NVS-PAK1-1, PAK1 inhibitor (ab146939)
Key features and details
- Potent allosteric inhibitor of PAK1
- CAS Number: 1783816-74-9
- Purity: > 98%
Soluble in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Lyophilized
- Source: Synthetic
Overview
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Product name
NVS-PAK1-1, PAK1 inhibitor -
Description
Potent allosteric inhibitor of PAK1 -
Biological description
NVS-PAK1-1 is a potent allosteric inhibitor of p21-activated kinase PAK1. It has an IC50 value of 5 nM for dephoshorylated PAK1 and 6 nM for phosphorylated PAK1 in an in vitro assay. It is more than 50-fold more active against PAK1 than against PAK2. NVS-PAK1-1 is highly selective in a panel of 442 kinases. NVS-PAK1-1 potently inhibits PAK1 autophosphorylation in cell-based assays.
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Purity
> 98% -
CAS Number
1783816-74-9 -
Chemical structure
Properties
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Chemical name
(S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide
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Molecular weight
479.93 -
Molecular formula
C23H25ClF3N5O -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in ethanol to 100 mM and in DMSO to 100 mM
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Handling
Refer to SDS for further information
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SMILES
O=C(NC(C)C)N4CC[C@H](NC1=Nc3cc(F)ccc3N(CC(F)F)c2ccc(Cl)cc12)C4 -
Source
Synthetic
