NPS 2143 hydrochloride, Ca2+-sensing receptor antagonist (ab145050)
Key features and details
- Potent, selective Ca2+-sensing receptor antagonist
- CAS Number: 324523-20-8
- Purity: > 99%
- Soluble in ethanol to 10 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
NPS 2143 hydrochloride, Ca2+-sensing receptor antagonist -
Description
Potent, selective Ca2+-sensing receptor antagonist -
Biological description
Potent, selective Ca2+-sensing receptor antagonist (IC50 = 43 nM). Stimulates parathyroid hormone secretion (EC50 = 41 nM). Shows antihypertensive effects in vivo. Orally active.
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Purity
> 99% -
CAS Number
324523-20-8 -
Chemical structure
Properties
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Chemical name
2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride -
Molecular weight
445.39 -
Molecular formula
C24H25ClN2O2.HCl -
PubChem identifier
9868131 -
Storage instructions
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 10 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)(CC1=CC2=CC=CC=C2C=C1)NC[C@H](COC3=C(C(=CC=C3)Cl)C#N)O.Cl -
Source
Synthetic
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Research areas
