NNC 711, GAT-1 inhibitor (ab120364)
Key features and details
- Potent, selective GAT-1 inhibitor
- CAS Number: 145645-62-1
- Purity: > 99%
- Soluble in water to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
NNC 711, GAT-1 inhibitor -
Description
Potent, selective GAT-1 inhibitor -
Biological description
Potent and selective GAT-1 GABA uptake inhibitor. (IC50 values are 0.04 (hGAT-1), 171 (rGAT-2), 1700 (hGAT-3) and 622 μM (hBGT-1)). Selective over a range of other neurotransmitter receptor binding sites, uptake sites and ion channels in vitro. Potent anticonvulsant, neuroprotectant and cognitive enhancer in vivo.
Also available in simple stock solutions (ab146719) - add 1 ml of water to get an exact, ready-to-use concentration. -
Purity
> 99% -
CAS Number
145645-62-1 -
Chemical structure
Properties
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Chemical name
1,2,5,6-Tetrahydro-1-[2-[[(diphenylmethylene)amino]oxy]ethyl]-3-pyridinecarboxylic acid hydrochloride -
Molecular weight
386.88 -
Molecular formula
C21H22N2O3.HCl -
PubChem identifier
123738 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.O=C(O)C=3CN(CCON=C(/c1ccccc1)c2ccccc2)CCC=3 -
Source
Synthetic
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Research areas
