NLG919, small molecule IDO pathway inhibitor (ab231505)
Key features and details
- Potent, small molecule IDO pathway inhibitor
- CAS Number: 1402836-58-1
Ethanol = 106.23 mM (30 mg/ml)
DMSO = 53.11 mM (15 mg/ml)(warmed)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
NLG919, small molecule IDO pathway inhibitor -
Description
Potent, small molecule IDO pathway inhibitor -
Biological description
NLG919 is a potent indoleamine 2,3-dioxygenase (IDO) pathway inhibitor (Ki = 7 nM; EC50 = 75 nM) in cell-free assays. It inhibits IDO-induced T cell suppression and restores T cell response during allogenic mixed lymphocyte reactions in vitro (ED50 = 80 and 120 nM, respectively). NLG919 promotes a 95% reduction in tumor volume in vivo when administered in conjunction with a pmel-1 T cell vaccine. NLG919 overcomes IDO-induced suppression of antigen-specific T-cells in in vitro models.
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Purity
100% -
CAS Number
1402836-58-1 -
Chemical structure
Properties
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Chemical name
1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol
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Molecular weight
282.39 -
Molecular formula
C18H22N2O -
PubChem identifier
66558287 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Ethanol = 106.23 mM (30 mg/ml)
DMSO = 53.11 mM (15 mg/ml)(warmed)
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SMILES
C1CCC(CC1)C(CC2C3=CC=CC=C3C4=CN=CN24)O -
Source
Synthetic
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Research areas
