Nimodipine, L-type Ca2+ channel blocker (ab120138)
Key features and details
- L-type Ca2+ channel blocker
- CAS Number: 66085-59-4
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Nimodipine, L-type Ca2+ channel blocker -
Description
L-type Ca2+ channel blocker -
Biological description
L-type Ca2+ channel blocker. Potent cerebrovasodilator. Cognitive enhancer. More lipophilic than nifedipine (ab120135).
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Purity
> 98% -
General notes
Nimodipine is light sensitive and it is recommended that the compound is protected from light.
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CAS Number
66085-59-4 -
Chemical structure
Images
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Functional Studies - Nimodipine, L-type Ca2+ channel blocker (ab120138)ab2770 staining aryl hydrocarbon receptor in MDA-MB-231 cells treated with nimodipine (ab120138), by ICC/IF. Increase in aryl hydrocarbon receptor expression correlates with increased concentration of nimodipine, as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab120138 (nimodipine) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab2770 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.