Nilotinib (AMN107), Bcr/Abl tyrosine kinase inhibitor (ab142019)
Key features and details
- Potent and selective Bcr/Abl tyrosine kinase inhibitor
- CAS Number: 641571-10-0
- Purity: > 99%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Nilotinib (AMN107), Bcr/Abl tyrosine kinase inhibitor -
Description
Potent and selective Bcr/Abl tyrosine kinase inhibitor -
Biological description
Potent and selective Bcr/Abl tyrosine kinase inhibitor (IC50 = 15 nM). JAK2/STAT5 inhibitor. Inhibits MDM2 at the post-translational level by inducing MDM2 self-ubiquitination and degradation. Shows antiproliferative and antitumor effects in vivo. Orally active. -
Purity
> 99% -
CAS Number
641571-10-0 -
Chemical structure
Properties
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Chemical name
4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzamide -
Molecular weight
529.52 -
Molecular formula
C28H22F3N7O -
PubChem identifier
644241 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)N3C=C(N=C3)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CC=C5 -
Source
Synthetic
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Research areas
