• Product name

  Native Human TIMP2 protein
  See all TIMP2 proteins and peptides

• Purity

  > 90 % SDS-PAGE.
  
  

• Expression system

  Native

• Accession

  P16035

• Protein length

  Full length protein

• Animal free

  No

• Nature

  Native

• • Species

    Human

• Alternative names

  • CSC 21K
  • CSC-21K
  • CSC21K

  • Metalloproteinase inhibitor 2
  • Metalloproteinase inhibitor 2 precursor
  • TIMP 2
  • TIMP metallopeptidase inhibitor 2
  • TIMP-2
  • TIMP2
  • TIMP2_HUMAN
  • Tissue Inhibitor of Metalloproteinase 2
  • Tissue inhibitor of metalloproteinases 2

  see all

• Function

  Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.

• Sequence similarities

  Belongs to the protease inhibitor I35 (TIMP) family.
  Contains 1 NTR domain.

• Post-translational
  modifications

  The activity of TIMP2 is dependent on the presence of disulfide bonds.

• Cellular localization

  Secreted.

• Target information above from: UniProt accession P16035 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt