Native Human Serum Albumin protein (Biotin) (ab8033)
Key features and details
- Expression system: Native
- Suitable for: Dot blot, ELISA, Immunomicroscopy, WB
-
Product name
Native Human Serum Albumin protein (Biotin)
See all Human Serum Albumin proteins and peptides -
Expression system
Native -
Protein length
Full length protein -
Animal free
No -
Nature
Native -
-
Species
Human -
Predicted molecular weight
69 kDa
-
-
Conjugation
Biotin -
Description
Native Human Human Serum Albumin protein (Biotin)
Preparation and Storage
-
Alternative names
- alb
- ALBU_HUMAN
- Albumin
see all -
Function
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. -
Tissue specificity
Plasma. -
Involvement in disease
Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population. -
Sequence similarities
Belongs to the ALB/AFP/VDB family.
Contains 3 albumin domains. -
Post-translational
modificationsKenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606.
Glycated in diabetic patients.
Phosphorylation sites are present in the extracelllular medium.
Acetylated on Lys-223 by acetylsalicylic acid. -
Cellular localization
Secreted. - Information by UniProt
Images
-
Dot Blot - Native Human Serum Albumin protein (Biotin) (ab8033)
Dot Blot - Native Human Serum Albumin protein (Biotin) (ab8033).
A three-fold serial dilution of ab8033 starting at 200ng was spotted onto 0.45 µm nitrocellulose and blocked in 1% BSA-TTBS for 30 min at 20°C. An HRP conjugated Streptavidin was incubated at 1/40,000 for 30 min at 20°C and imaged using the Bio-Rad VersaDoc® 4000 MP.
