Native Collagen V protein (ab7530)
Key features and details
- Expression system: Native
- Suitable for: WB, IP, ELISA
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Product name
Native Collagen V protein
See all Collagen V proteins and peptides -
Biological activity
Collagen taken from bovine species. -
Expression system
Native -
Protein length
Full length protein -
Animal free
No -
Nature
Native
Preparation and Storage
-
Alternative names
- AB collagen
- Alpha 1 type V collagen
- Alpha 2 type V collagen
see all -
Function
Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. -
Involvement in disease
Ehlers-Danlos syndrome 1
Ehlers-Danlos syndrome 2 -
Sequence similarities
Belongs to the fibrillar collagen family.
Contains 1 fibrillar collagen NC1 domain.
Contains 1 laminin G-like domain. -
Domain
The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function. -
Post-translational
modificationsProlines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Sulfated on 40% of tyrosines. -
Cellular localization
Secreted > extracellular space > extracellular matrix. - Information by UniProt
