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N-Desmethyl clozapine (Normethylclozapine), Clozapine metabolite. M1 agonist. D2/D3 agonist. (ab120026)

Key features and details

  • Clozapine metabolite. M1 agonist. D2/D3 agonist.
  • CAS Number: 6104-71-8
  • Purity: > 99%
  • Soluble in DMSO to 100 mM
  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    N-Desmethyl clozapine (Normethylclozapine), Clozapine metabolite. M1 agonist. D2/D3 agonist.

  • Description

    Clozapine metabolite. M1 agonist. D2/D3 agonist.

  • Alternative names

    • Normethylclozapine

  • Biological description

    Brain penetrant metabolite of the atypical antipsychotic clozapine. Broad range of actions. Potent allosteric M1 partial agonist (IC50 = 55 nM for inhibition of [3H]-NMS binding). D2/D3 partial agonist. Also displays affinity at 5-HT1 and 5-HT2.

  • Purity

    > 99%

  • CAS Number

    6104-71-8

  • Chemical structure

    Chemical Structure

Images

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