Mz1, selectively degrades BRD4 (ab230371)
Key features and details
- (+)-JQ1 based PROTAC that selectively degrades BRD4
- CAS Number: 1797406-69-9
- Purity: > 98%
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Mz1, selectively degrades BRD4 -
Description
(+)-JQ1 based PROTAC that selectively degrades BRD4 -
Biological description
Cell penetrant PROTAC (Proteolysis Targeting Chimera) compound based on (+)-JQ1 (ab141498) tethered to a von Hippel-Lindau (VHL) ligand. Retains high affinity for BRD2, BRD3 and BRD4 bromodomains. Induces preferential degradation of BRD4 over BRD2 and BRD3 in HeLa cells.
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Purity
> 98% -
CAS Number
1797406-69-9 -
Chemical structure
Properties
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Chemical name
(2S,4R)-1-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2- f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide -
Molecular weight
1002.64 -
Molecular formula
C49H60ClN9O8S2 -
PubChem identifier
122201421 -
Storage instructions
Shipped at 4°C. Store at -20°C. -
SMILES
CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)NCCOCCOCCOCC(=O)NC(C(=O)N4CC(CC4C(=O)NCC5=CC=C(C=C5)C6=C(N=CS6)C)O)C(C)(C)C)C7=CC=C(C=C7)Cl)C -
Source
Synthetic
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Research areas
