ML 218, T-type Ca2+ channel and hERG channel blocker (ab145549)
Key features and details
- Potent, selective T-type Ca2+ channel and hERG channel blocker
- CAS Number: 1346233-68-8
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
ML 218, T-type Ca2+ channel and hERG channel blocker -
Description
Potent, selective T-type Ca2+ channel and hERG channel blocker -
Biological description
Potent, selective T-type Ca2+ channel and hERG channel blocker (IC50 values are 150, 310 and 270 nM for Cav3.2 in Ca2+ flux, Cav3.2 and Cav3.3 respectively). ML 218 hydrochloride (ab145550) analog. Shows antiparkinson effects in vivo. Orally active. -
Purity
> 98% -
CAS Number
1346233-68-8 -
Chemical structure
Properties
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Chemical name
3,5-Dichloro-N-[[(1R,5S)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl]benzamide -
Molecular weight
369.33 -
Molecular formula
C19H26Cl2N2O -
PubChem identifier
45115620 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)(C)CCN1C[C@@H]2[C@H](C1)C2CNC(=O)C3=CC(=CC(=C3)Cl)Cl -
Source
Synthetic
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Research areas
