MK-1775 (ab147242)
Key features and details
- Potent and selective small-molecule inhibitor of Wee1 kinase
- CAS Number: 955365-80-7
- Purity: > 98%
Soluble in DMSO to 200 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
MK-1775 -
Description
Potent and selective small-molecule inhibitor of Wee1 kinase -
Alternative names
- AZD 1775
- MK1775
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Biological description
Potent and selective small-molecule inhibitor of Wee1 kinase. Inhibits Wee1 (IC50 = 5.2 nM) in cell-free assays. Inhibits phosphorylation of CDC2 at Tyr15 (CDC2Y15), a direct substrate of Wee1 kinase in cell-based assays. Acts synergistically with gemcitabine in tumor cells. In a panel of 223 kinases, only 8 were inhibited >80% by 1μM MK-1775.
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Purity
> 98% -
CAS Number
955365-80-7 -
Chemical structure
Properties
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Chemical name
1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-3H-pyrazolo [3,4-d]pyrimidin-3-one
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Molecular weight
500.60 -
Molecular formula
C27H32N8O2 -
PubChem identifier
24856436 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in DMSO to 200 mM
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Handling
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)C)O -
Source
Synthetic
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Research areas
Images
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Chemical Structure - MK-1775 (ab147242)
Chemical structure of MK-1775, 955365-80-7
