Function: Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication. Medin is the main constituent of aortic medial amyloid. Tissue specificity: Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas. Similarity: Contains 1 EGF-like domain. Contains 2 F5/8 type C domains. PTM: Medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273.