MG-132 (Ethanol Solution), proteasome inhibitor (ab147047)
Key features and details
- Cell-permeable, potent, reversible proteasome inhibitor
- CAS Number: 133407-82-6
- Purity: > 98%
- Supplied in ethanol (10 mM)
- Form / State: Liquid
- Source: Synthetic
Overview
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Product name
MG-132 (Ethanol Solution), proteasome inhibitor -
Description
Cell-permeable, potent, reversible proteasome inhibitor -
Alternative names
- Z-Leu-Leu-Leu-CHO
- Z-LLL-CHO
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Biological description
Cell-permeable, potent, reversible proteasome inhibitor (Ki = 4 nM). Reduces degradation of ubiquitin-conjugated proteins in mammalian cells by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-kB activation. Anticancer properties in vitro and in vivo.
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Purity
> 98% -
General notes
Desiccate at -20°C in a spark free freezer [product contains a flammable solvent (UN1170: ethanol solution, PG II)]. Protect from air and moisture.
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CAS Number
133407-82-6 -
Chemical structure
Properties
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Molecular weight
475.62 -
Molecular formula
C26H41N3O5 -
Sequence
LLL (Modifications : N-terminal benzyloxycarbonyl; C-terminal aldehyde) -
PubChem identifier
462382 -
Storage instructions
Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Supplied in ethanol (10 mM) -
Handling
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas
