Methyclothiazide, Thiazide diuretic (ab145735)
Key features and details
- Thiazide diuretic, used to treat high blood pressure and fluid retention
- CAS Number: 135-07-9
- Soluble in DMSO to 100 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Methyclothiazide, Thiazide diuretic -
Description
Thiazide diuretic, used to treat high blood pressure and fluid retention -
Alternative names
- 6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
- Enduron
- MCTZ
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Biological description
Substituted benzothiadiazide. Exhibits an inhibitory effect on Ca2+ contracture which is significantly but not totally abolished by an NO synthase inhibitor in spontaneously hypertensive rats (SHR) aortic rings with functional endothelium. Induces endothelium-dependent inhibition of the vasoconstrictor responses to norepinephrine and arginine vasopressin only in aortas from SHR rather than normotensive Wistar Kyoto rats (WKY). Inhibits renin release in rat kidney slices.
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CAS Number
135-07-9 -
Chemical structure
Properties
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Chemical name
6-Chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide -
Molecular weight
360.24 -
Molecular formula
C9H11Cl2N3O4S2 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
