LX-1031, TPH1 inhibitor (ab269814)
Key features and details
- TPH1 inhibitor
- CAS Number: 945976-76-1
Soluble in water to 5 mM and in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
LX-1031, TPH1 inhibitor -
Description
TPH1 inhibitor -
Biological description
Small molecule inhibitor of tryptophan 5-hydroxylase (TPH). A heterocyclic substituted phenylalanine analog. Inhibits TPH1 in vitro in the concentration range 10-7 - 10-8 M. Reduces synthesis of serotonin (5-HT) peripherally and is being developed for conditions characterized by excess 5-HT expression such as diarrhea-predominant irritable bowel syndrome (IBS-D) and possibly carcinoid diarrhea.
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CAS Number
945976-76-1 -
Chemical structure
Properties
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Chemical name
4-[2-Amino-6-[(1R)-2,2,2-trifluoro-1-(3'-methoxy[1,1'-biphenyl]-4- yl)ethoxy]-4-pyrimidinyl]-L-phenylalanine
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Molecular weight
538.52 -
Molecular formula
C28H25F3N4O4 -
PubChem identifier
23633604 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in water to 5 mM and in DMSO to 50 mM
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Handling
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC1=CC=CC(=C1)C2=CC=C(C=C2)[C@H](C(F)(F)F)OC3=NC(=NC(=C3)C4=CC=C(C=C4)C[C@@H](C(=O)O)N)N -
Source
Synthetic
Images
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Chemical Structure - LX-1031, TPH1 inhibitor (ab269814)
Chemical structure of LX-1031, TPH1 inhibitor, 945976-76-1