Lifitegrast, LFA-1 (lymphocyte function-associated antigen-1) antagonist (ab235456)
Key features and details
- LFA-1 (lymphocyte function-associated antigen-1) antagonist
- CAS Number: 1025967-78-5
- Purity: > 98%
DMSO >30 mg/mL
Ethanol 20 mg/mL
Insoluble in water
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Lifitegrast, LFA-1 (lymphocyte function-associated antigen-1) antagonist -
Description
LFA-1 (lymphocyte function-associated antigen-1) antagonist -
Alternative names
- SAR-1118
- SAR1118
- Xiidra
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Biological description
LFA-1 (lymphocyte function-associated antigen-1) antagonist intended for the treatment of vascular complications of the eye. Lifitegrast is a novel T-cell integrin antagonist that is designed to mimic the binding epitope of ICAM-1. It acts as a molecular decoy to block the LFA-1/ICAM-1 interaction and thus inhibits downstream inflammatory responses.
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Purity
> 98% -
CAS Number
1025967-78-5 -
Chemical structure
Properties
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Chemical name
(S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid
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Molecular weight
615.48 -
Molecular formula
C29H24Cl2N2O7S -
PubChem identifier
335987004 -
Storage instructions
Shipped at Room Temperature. Store at -20°C. Store In the Dark. Store under desiccating conditions. -
Solubility overview
DMSO >30 mg/mL
Ethanol 20 mg/mL
Insoluble in water
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CS(=O)(=O)C1=CC=CC(=C1)CC(C(=O)O)NC(=O)C2=C(C=C3CN(CCC3=C2Cl)C(=O)C4=CC5=C(C=C4)C=CO5)Cl -
Source
Synthetic
