Letrozole, Aromatase inhibitor (ab141293)
Key features and details
- Highly potent, reversible, selective aromatase inhibitor
- CAS Number: 112809-51-5
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
Letrozole, Aromatase inhibitor -
Description
Highly potent, reversible, selective aromatase inhibitor -
Biological description
Highly potent, reversible, selective aromatase inhibitor (IC50 = 11.5 nM). Inhibits estradiol synthesis. Potent antitumor effects in vivo. Cytochrome P450 inhibitor.
-
Purity
> 99% -
CAS Number
112809-51-5 -
Chemical structure
Properties
-
Chemical name
4,4'-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile -
Molecular weight
285.31 -
Molecular formula
C17H11N5 -
PubChem identifier
3902 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
N#Cc1ccc(cc1)C(c2ccc(C#N)cc2)n3cncn3 -
Source
Synthetic
-
Research areas
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Cholesterol Metabolism
