Penitrem A, blocker of KCa1.1 (ab141842)
Key features and details
- Selective blocker of KCa1.1
- CAS Number: 12627-35-9
- Purity: > 98%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Penicillium palitans
Overview
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Product name
Penitrem A, blocker of KCa1.1 -
Description
Selective blocker of KCa1.1 -
Biological description
Potent, selective BKCa blocker (IC50 values are 6 and 60 nM for α-subunit and mixed α- and β1-subunit containing channels respectively). No effect on native delayed rectifier K+ currents, cloned voltage-dependent Kv1.5 channels, or KATP currents. Inhibits BK channels in inside-out and cell-attached patches. Tremorgenic effects and increases total peripheral resistance in vivo. Orally active. -
Purity
> 98% -
CAS Number
12627-35-9 -
Chemical structure
Properties
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Chemical name
(2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9a-,14bS,14cR,16aS)-12-Chloro-3,3a,6a,8,9,9a,10,11,14-,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-te-tramethyl-10-methylene-2-(1-methylethenyl)-7,8-(ep-oxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno-[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3-,4b,7d(5H,7H)-triol -
Molecular weight
634.20 -
Molecular formula
C37H44ClNO6 -
PubChem identifier
44450809 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(=C)C1C(C2C3(O2)C(O1)CCC4(C3(CCC5C4(C6=C7C5OC(C8CC9C8(C1=C7C(=CC(= C1CC9=C)Cl)N6)O)(C)C)C)O)C)O -
Source
Penicillium palitans
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Research areas