Leflunomide, Immunomodulatory agent (ab141479)
Key features and details
- Immunomodulatory agent
- CAS Number: 75706-12-6
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Leflunomide, Immunomodulatory agent -
Description
Immunomodulatory agent -
Biological description
Immunomodulatory agent. Inhibits dihydroorotate dehydrogenase (Ki = 2.7 μM). Inhibits T and B cell activity and prevents lymphocyte cell cycle proliferation and progression. Also shows anti-inflammatory activity. Active In vivo. -
Purity
> 98% -
CAS Number
75706-12-6 -
Chemical structure
Properties
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Chemical name
5-Methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide -
Molecular weight
270.21 -
Molecular formula
C12H9F3N2O2 -
PubChem identifier
3899 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=C(C=NO1)C(=O)NC2=CC=C(C=C2)C(F)(F)F -
Source
Synthetic
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Research areas
- Epigenetics and Nuclear Signaling
- Transcription
- Domain Families
- HLH / Leucine Zipper
- Helix-Turn-Helix
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Orphan Nuclear Receptors
- Epigenetics and Nuclear Signaling
- Chromatin Modifying Enzymes
- Acetylation
- HDACs
- Class II / Hda1 Class
