Lapatinib, EGFR and HER2 tyrosine kinase inhibitor (ab219408)
Key features and details
- Cell-permeable, potent EGFR and HER2 tyrosine kinase inhibitor
- CAS Number: 231277-92-2
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Lapatinib, EGFR and HER2 tyrosine kinase inhibitor -
Description
Cell-permeable, potent EGFR and HER2 tyrosine kinase inhibitor -
Alternative names
- GSK572016
- GW 572016
- GW572016
- Tyverb
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Biological description
Cell-permeable, potent dual tyrosine kinase inhibitor of EGFR and HER2 (ERBB2) (IC50 values are 3 nM and 13 nM respectively). Also inhibits HER4 (IC50 = 347 nM). Reduces tyrosine phosphorylation of EGFR and HER2, and inhibits activation of Erk1/2 and AKT, downstream effectors of proliferation and cell survival, respectively. Inhibits tumor cell growth in vitro and in xenograft models for a variety of human tumors. Effective in vivo and is used in combination therapy to prevent or suppress cancers where these kinases are over-
expressed, including breast cancer. -
Purity
> 98% -
CAS Number
231277-92-2 -
Chemical structure
Properties
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Chemical name
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine -
Molecular weight
581.06 -
Molecular formula
C29H26ClFN4O4S -
PubChem identifier
208908 -
Storage instructions
Shipped at Room Temperature. Store at -20°C long term. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl -
Source
Synthetic
