L-745870 trihydrochloride, brain penetrant D4 antagonist (ab120598)
Key features and details
- Highly potent, selective brain penetrant D4 antagonist
- CAS Number: 866021-03-6
- Purity: > 99%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
L-745870 trihydrochloride, brain penetrant D4 antagonist -
Description
Highly potent, selective brain penetrant D4 antagonist -
Biological description
Highly potent and selective D4 antagonist (Ki values are 0.43, 2300 and 960 nM at D4, D3 and D2, respectively). Brain permeable. Inhibits cell death and shows neuroprotective effects.
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Purity
> 99% -
CAS Number
866021-03-6 -
Chemical structure
Properties
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Chemical name
3-[4-(4-Chlorophenyl)piperazin-1-yl]-methyl-1H-pyrrolo[2,3-b]pyridine trihydrochloride -
Molecular weight
436.21 -
Molecular formula
C18H19ClN4.3HCl -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas
