Kobe0065, H-Ras-c-Raf1 interaction inhibitor (ab235574)
Key features and details
- Small molecule inhibitor of the H-Ras-c-Raf1 interaction
- CAS Number: 436133-68-5
- Purity: > 98%
DMSO 89 mg/mL (197.87 mM)
Ethanol 13 mg/mL (28.9 mM)
Insoluble in water
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Kobe0065, H-Ras-c-Raf1 interaction inhibitor -
Description
Small molecule inhibitor of the H-Ras-c-Raf1 interaction -
Biological description
Kobe0065 is small molecule inhibitor of the H-Ras-c-Raf interaction. It competitively inhibits the binding of H-Ras•GTD to c-Raf1 RBD with an IC50 of 46 μM. Exhibits antiproliferative activity in xenografts of SW480 colon carcinoma cells carrying the K-rasG12Vgene. Inhibits anchorage-depoendent and independent growth and induces apotosis of NIH/3T3 cells transformed with K-rasG12V. Growth inhibition is accompanied by the down regulaton MEK/ERK, Akt, RalA, and Sos suggesting Kobe0065 blocks the interaction of H-Ras•GTp with mutiple effectors.
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Purity
> 98% -
CAS Number
436133-68-5 -
Chemical structure
Properties
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Chemical name
N-(3-chloro-4-methylphenyl)-2-(2,6-dinitro-4-(trifluoromethyl)phenyl)hydrazinecarbothioamide
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Molecular weight
449.79 -
Molecular formula
C15H11ClF3N5O4S -
PubChem identifier
3827663 -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. It is important to note that this is air sensitive and impurities can occur as a result of air oxidation. Store In the Dark. Store under desiccating conditions. -
Solubility overview
DMSO 89 mg/mL (197.87 mM)
Ethanol 13 mg/mL (28.9 mM)
Insoluble in water
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=C(C=C(C=C1)NC(=S)NNC2=C(C=C(C=C2[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-])Cl -
Source
Synthetic
