Astana Biomed Group, an authorized Abcam distributor in Central Asia

ISRIB (trans-isomer) (ab273604)

Key features and details

  • Potent and selective PERK inhibitor
  • CAS Number: 1597403-47-8
  • Purity: > 96%

  • Soluble in DMSO to 10 mM with gentle warming

  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    ISRIB (trans-isomer)

  • Description

    Potent and selective PERK inhibitor

  • Biological description

    Potent and selective PERK inhibitor with IC50 of 5 nM. Integrated stress response (ISR) inhibitor.

  • Purity

    > 96%

  • CAS Number

    1597403-47-8

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N,N'-trans-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide]

  • Molecular weight

    451.34

  • Molecular formula

    C22H24Cl2N2O4

  • PubChem identifier

    1011240

  • Storage instructions

    Shipped at room temperature. Store at -20°C.

  • Solubility overview

    Soluble in DMSO to 10 mM with gentle warming

  • Handling

    Refer to SDS for further information

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CC(CCC1NC(=O)COC2=CC=C(C=C2)Cl)NC(=O)COC3=CC=C(C=C3)Cl

  • Source

    Synthetic

Images

  • Chemical Structure - ISRIB (trans-isomer) (ab273604)
    Chemical Structure - ISRIB (trans-isomer) (ab273604)

    Chemical structure of ISRIB (trans-isomer), 1597403-47-8

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