Ifenprodil hemitartrate, GluN2B (formerly NR2B)-preferring NMDA antagonist (ab120111)
Key features and details
- GluN2B (formerly NR2B)-preferring NMDA antagonist
- CAS Number: 23210-58-4
- Purity: > 99%
- Soluble in water to 15 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Ifenprodil hemitartrate, GluN2B (formerly NR2B)-preferring NMDA antagonist -
Description
GluN2B (formerly NR2B)-preferring NMDA antagonist -
Biological description
Non-competitive NMDA receptor antagonist acting at the polyamine site. Displays GluN2B (formerly NR2B) subunit selectivity. IC50 values are 0.15 μM at NR1/NR2B and >30 μM for NR1/NR2A, NR1/NR2C and NR1/NR2D receptors.
Also available in simple stock solutions (ab146675) - add 1 ml of water to get an exact, ready-to-use concentration. -
Purity
> 99% -
CAS Number
23210-58-4 -
Chemical structure
Properties
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Chemical name
erythro-4-(2-(4-Benzylpiperidin-1-yl)-1-hydroxypropyl)phenol hemitartrate -
Molecular weight
400.49 -
Molecular formula
C21H27NO2.0.5C4H6O6 -
PubChem identifier
656586 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 15 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C(C1=CC=C(C=C1)O)O)N2CCC(CC2)CC3=CC=CC=C3.CC(C(C1=CC=C(C=C1)O)O)N2CCC(CC2)CC3=CC=CC=C3.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O -
Source
Synthetic
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Research areas
Images
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Functional Studies - Ifenprodil hemitartrate, GluN2B (formerly NR2B)-preferring NMDA antagonist (ab120111) Image from Case DT et al., PLoS One. 2011;6(6):e20756. Fig 4(D).; doi: 10.1371/journal.pone.0020756. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/Median ifenprodil sensitivity from a rat postnatal day 2 (P2) and day 12 (P12) neuron; NMDAR-mediated responses in control (black) and in presence of the GluN2B-preferring antagonist ifenprodil (ab120111, grey).