Ibrutinib (PCI-32765), BTK inhibitor (ab254447)
Key features and details
- Highly potent, irreversible BTK inhibitor
- CAS Number: 936563-96-1
- Purity: > 99%
Soluble in DMSO to 50mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Ibrutinib (PCI-32765), BTK inhibitor -
Description
Highly potent, irreversible BTK inhibitor -
Alternative names
- PCI-32765
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Biological description
Highly potent, irreversible Bruton tyrosine kinase (BTK) inhibitor (IC50 = 0.5nM). Inhibits autophosphorylation of BTK IC50 = 11 nM), and phophorylation of PLCγ (IC50 = 29 nM) and ERK (IC50 = 13 nM). Potently inhbits BLK, BMS, FGR, EGFR and ITK kinases. Blocks B-cell antigen receptor (BCR) activation. Cytotoxic to chronic lymphocytic leukemia (CLL) cells.
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Purity
> 99% -
General notes
Solutions in DMSO may be stored at -20°C for up to 3 months.
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CAS Number
936563-96-1 -
Chemical structure
Properties
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Chemical name
1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one
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Molecular weight
440.50 -
Molecular formula
C25H24N6O2 -
PubChem identifier
24821094 -
Storage instructions
Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 50mM
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Handling
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C=CC(=O)N1CCC[C@H](C1)N2C3=C(C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=NC=N3)N -
Source
Synthetic
