Astana Biomed Group, an authorized Abcam distributor in Central Asia

Human TAB2 Antibody Pair - BSA and Azide free (ab241858)

Key features and details

  • Unconjugated capture and detector antibodies
  • Adaptable to any antibody pair-based assay format
  • Antibody concentration ~ 1 mg/ml
  • BSA and azide free buffer - ready for conjugation
  • Reacts with: Human

Overview

  • Product name

    Human TAB2 Antibody Pair - BSA and Azide free

  • Assay type

    ELISA set

  • Range

    125 pg/ml - 8000 pg/ml

  • Species reactivity

    Reacts with: Human

  • Product overview

    The Antibody Pair can be used to quantify Human TAB2. BSA and Azide free antibody pairs include unconjugated capture and detector antibodies suitable for sandwich ELISAs. The antibodies are provided at an approximate concentration of 1 mg/ml as measured by the protein A280 method. The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Both capture and detector antibodies are rabbit monoclonal antibodies delivering consistent, specific, and sensitive results.


    For additional information on the performance of the antibody pair, see the equivalent SimpleStep ELISA® Kit (ab215534), which uses the same antibodies. However, due to differences in their formulation, this antibody pair cannot be used with the consumables provided with our SimpleStep ELISA Kits. Please note that the range provided for the pairs is only an estimation based on the performance of the related product using the same antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody pair in your assay.


    Download SDS here.

  • Tested applications

    Suitable for: Sandwich ELISAmore details

  • Platform

    Reagents

Properties

  • Storage instructions

    Store at +4°C. Please refer to protocols.

  • Carrier free

    Yes
  • Components 10 x 96 tests
    Human TAB2 Capture Antibody (unconjugated) 1 x 100µg
    Human TAB2 Detector Antibody (unconjugated) 1 x 100µg

  • Research areas

  • Function

    Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development.

  • Tissue specificity

    Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves.

  • Involvement in disease

    Defects in TAB2 are the cause of congenital heart disease non-syndromic type 2 (CHTD2) [MIM:612863]. It is a disease characterized by congenital developmental abnormalities involving structures of the heart. Clinical features include left ventricular outflow tract obstruction, subaortic stenosis, residual aortic regurgitation, atrial fibrillation, bicuspid aortic valve and aortic dilation. Note=A chromosomal aberration involving TAB2 has been found in a family with congenital heart disease. Translocation t(2;6)(q21;q25).

  • Sequence similarities

    Contains 1 CUE domain.
    Contains 1 RanBP2-type zinc finger.

  • Post-translational
    modifications

    Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Ubiquitination involves RBCK1 leading to proteasomal degradation.
    Phosphorylated.

  • Cellular localization

    Membrane. Cytoplasm > cytosol. Following IL1 stimulation, translocation occurs from the membrane to cytosol.
  • Information by UniProt

  • Alternative names

    • CHTD2
    • FLJ21885
    • KIAA0733
    • MAP3K7IP2
    • Mitogen activated protein kinase kinase kinase 7 interacting protein 2
    • Mitogen-activated protein kinase kinase kinase 7-interacting protein 2
    • OTTHUMP00000040125
    • TAB 2
    • TAB-2
    • Tab2
    • TAB2_HUMAN
    • TAK1 binding protein 2
    • TAK1-binding protein 2
    • TGF beta activated kinase 1/MAP3K7 binding protein 2
    • TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
    • TGF-beta-activated kinase 1-binding protein 2
    see all

  • Database links

    Images

    • Sandwich ELISA - Human TAB2 Antibody Pair - BSA and Azide free (ab241858)
      Sandwich ELISA - Human TAB2 Antibody Pair - BSA and Azide free (ab241858)
      To learn more about the advantages of recombinant antibodies see here.

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