Human Niemann Pick C2 Antibody Pair - BSA and Azide free (ab244041)
Key features and details
- Unconjugated capture and detector antibodies
- Adaptable to any antibody pair-based assay format
- Antibody concentration ~ 1 mg/ml
- BSA and azide free buffer - ready for conjugation
- Reacts with: Human
Overview
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Product name
Human Niemann Pick C2 Antibody Pair - BSA and Azide free
See all Niemann Pick C2 kits -
Assay type
ELISA set -
Range
19 pg/ml - 1200 pg/ml -
Species reactivity
Reacts with: Human -
Product overview
The Antibody Pair can be used to quantify Human Niemann Pick C2. BSA and Azide free antibody pairs include unconjugated capture and detector antibodies suitable for sandwich ELISAs. The antibodies are provided at an approximate concentration of 1 mg/ml as measured by the protein A280 method. The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Both capture and detector antibodies are rabbit monoclonal antibodies delivering consistent, specific, and sensitive results.
For additional information on the performance of the antibody pair, see the equivalent SimpleStep ELISA® Kit (ab227894), which uses the same antibodies. However, due to differences in their formulation, this antibody pair cannot be used with the consumables provided with our SimpleStep ELISA Kits. Please note that the range provided for the pairs is only an estimation based on the performance of the related product using the same antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody pair in your assay.
Download SDS here.
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Tested applications
Suitable for: Sandwich ELISAmore details -
Platform
Reagents
Properties
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Storage instructions
Store at +4°C. Please refer to protocols. -
Carrier free
Yes -
Components 10 x 96 tests Human Neuropilin-1 Capture Antibody (unconjugated) 1 x 100µg Human Neuropilin-1 Detector Antibody (unconjugated) 1 x 100µg -
Research areas
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Function
May be involved in the regulation of the lipid composition of sperm membranes during the maturation in the epididymis. -
Tissue specificity
Epididymis. -
Involvement in disease
Defects in NPC2 are the cause of Niemann-Pick disease type C2 (NPDC2) [MIM:607625]. A lysosomal storage disorder that affects the viscera and the central nervous system. It is due to defective intracellular processing and transport of low-density lipoprotein derived cholesterol. It causes accumulation of cholesterol in lysosomes, with delayed induction of cholesterol homeostatic reactions. Niemann-Pick disease type C2 has a highly variable clinical phenotype. Clinical features include variable hepatosplenomegaly and severe progressive neurological dysfunction such as ataxia, dystonia and dementia. The age of onset can vary from infancy to late adulthood. -
Sequence similarities
Belongs to the NPC2 family. -
Cellular localization
Secreted. - Information by UniProt
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Alternative names
- EDDM1
- Epididymal protein 1
- Epididymal secretory protein
see all -
Database links
- Entrez Gene: 10577 Human
- Omim: 601015 Human
- SwissProt: P61916 Human
- Unigene: 433222 Human
Images
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Sandwich ELISA - Human Niemann Pick C2 Antibody Pair - BSA and Azide free (ab244041)To learn more about the advantages of recombinant antibodies see here.