Human IFN alpha/beta R2 (IFNAR2) Antibody Pair - BSA and Azide free (ab267718)
Key features and details
- Unconjugated capture and detector antibodies
- Adaptable to any antibody pair-based assay format
- Antibody concentration ~ 1 mg/ml
- BSA and azide free buffer - ready for conjugation
Overview
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Product name
Human IFN alpha/beta R2 (IFNAR2) Antibody Pair - BSA and Azide free
See all IFNAR2 kits -
Assay type
ELISA set -
Range
46.875 pg/ml - 3000 pg/ml -
Product overview
The Antibody Pair can be used to quantify Human IFN alpha/beta R2. BSA and Azide free antibody pairs include unconjugated capture and detector antibodies suitable for sandwich ELISAs. The antibodies are provided at an approximate concentration of 1 mg/ml as measured by the protein A280 method. The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Both capture and detector antibodies are rabbit monoclonal antibodies delivering consistent, specific, and sensitive results.
For additional information on the performance of the antibody pair, see the equivalent SimpleStep ELISA® Kit (ab264610), which uses the same antibodies. However, due to differences in their formulation, this antibody pair cannot be used with the consumables provided with our SimpleStep ELISA Kits. Please note that the range provided for the pairs is only an estimation based on the performance of the related product using the same antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody pair in your assay.
Download SDS here.
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Tested applications
Suitable for: Sandwich ELISAmore details -
Platform
Reagents
Properties
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Storage instructions
Store at +4°C. Please refer to protocols. -
Carrier free
Yes -
Components 10 x 96 tests Human IFN alpha/beta R2 (IFNAR2) Capture Antibody (unconjugated) 1 x 100µg Human IFN alpha/beta R2 (IFNAR2) Detector Antibody (unconjugated) 1 x 100µg -
Research areas
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Function
Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. -
Tissue specificity
Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines. -
Sequence similarities
Belongs to the type II cytokine receptor family. -
Post-translational
modificationsPhosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types.
Glycosylated. -
Cellular localization
Secreted and Membrane. - Information by UniProt
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Alternative names
- Human interferon alpha/beta receptor
- IFN alpha REC
- IFN R
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Images
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Sandwich ELISA - Human IFN alpha/beta R2 (IFNAR2) Antibody Pair - BSA and Azide free (ab267718)To learn more about the advantages of recombinant antibodies see here.
