Human Growth Hormone ELISA Kit (ab108643)
Key features and details
- Sensitivity: 0.5 ng/ml
- Range: 0.5 ng/ml - 50 ng/ml
- Sample type: Serum
- Detection method: Colorimetric
- Assay type: Sandwich (quantitative)
- Reacts with: Human
Overview
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Product name
Human Growth Hormone ELISA Kit
See all Growth Hormone kits -
Detection method
Colorimetric -
Sample type
Serum -
Assay type
Sandwich (quantitative) -
Sensitivity
= 0.5 ng/ml -
Range
0.5 ng/ml - 50 ng/ml -
Assay duration
Multiple steps standard assay -
Species reactivity
Reacts with: Human -
Product overview
ab108643 Human Growth Hormone Human ELISA Kit is intended for the quantitative determination of the Human Growth Hormone (HGH) concentration in human serum.
Human Growth Hormone (HGH, somatotropin) is a polypeptide secreted by the anterior pituitary. It is 191 amino acids in length and has a molecular mass of approximately 22,000 daltons. Its metabolic effects are primarily anabolic. Human Growth Hormone promotes protein conservation and is engaged in a wide range of mechanisms for protein synthesis. It also enhances glucose transport and facilitates glycogen storage. Its cascade of growth-promoting action is mediated by another family of peptide hormones, the somatomedins. Human Growth Hormone measurement is primarily of interest in the diagnosis and treatment of various forms of abnormal growth hormone secretion. Disorders caused by hyposecretion include dwarfism and unattained growth potential, and hypersecretion is associated with gigantism and acromegaly.
Get results in 90 minutes with Human Growth Hormone ELISA Kit (ab190811) from our SimpleStep ELISA® range.
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Platform
Microplate
Properties
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Storage instructions
Store at +4°C. Please refer to protocols. -
Components 1 x 96 tests Enzyme Conjugate Reagent 1 x 13ml HGH Standard 5 ng/ml 1 x 1ml HGH Standard 0 ng/ml 1 x 1ml HGH Standard 10 ng/ml 1 x 1ml HGH Standard 2.5 ng/ml 1 x 1ml HGH Standard 25 ng/ml 1 x 1ml HGH Standard 50 ng/ml 1 x 1ml Sheep Anti-Human Growth Hormone-Coated microtiter plate 1 x 96 tests Stop Solution 1 x 12ml TMB Reagent 1 x 11ml -
Research areas
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Function
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. -
Involvement in disease
Defects in GH1 are a cause of growth hormone deficiency isolated type 1A (IGHD1A) [MIM:262400]; also known as pituitary dwarfism I. IGHD1A is an autosomal recessive deficiency of GH which causes short stature. IGHD1A patients have an absence of GH with severe dwarfism and often develop anti-GH antibodies when given exogenous GH.
Defects in GH1 are a cause of growth hormone deficiency isolated type 1B (IGHD1B) [MIM:612781]; also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Dwarfism is less severe than in IGHD1A and patients usually respond well to exogenous GH.
Defects in GH1 are the cause of Kowarski syndrome (KWKS) [MIM:262650]; also known as pituitary dwarfism VI.
Defects in GH1 are a cause of growth hormone deficiency isolated type 2 (IGHD2) [MIM:173100]. IGHD2 is an autosomal dominant deficiency of GH which causes short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy. -
Sequence similarities
Belongs to the somatotropin/prolactin family. -
Cellular localization
Secreted. - Information by UniProt
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Alternative names
- gH
- GH-N
- GH1
see all -
Database links
- Entrez Gene: 2688 Human
- Omim: 139250 Human
- SwissProt: P01241 Human
- Unigene: 655229 Human
Images
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ELISA - Human Growth Hormone Human ELISA Kit (ab108643)Human Growth Hormone Standard curve
