Human CD130 ELISA Kit (GP130) (ab46135)
Key features and details
- Sensitivity: 15 pg/ml
- Range: 56.25 pg/ml - 1800 pg/ml
- Sample type: Cell culture supernatant, Plasma, Serum
- Detection method: Colorimetric
- Assay type: Sandwich (quantitative)
- Reacts with: Human
Properties
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Storage instructions
Store at +4°C. Please refer to protocols. -
Components Identifier 1 x 96 tests 2 x 96 tests 10X Standard Diluent Buffer Black 1 x 15ml 2 x 25ml 200X Wash Buffer White 1 x 10ml 2 x 10ml Biotinylated Antibody Diluent Red 1 x 7.5ml 1 x 13ml Biotinylated anti-CD130 Red 1 x 400µl 2 x 400µl CD130 Microplate (12 x 8 well strips) 1 unit 2 units CD130 Standard (lyophilized) Yellow 2 vials 4 vials Chromogen TMB Substrate Solution 1 x 11ml 1 x 24ml Control Silver 2 vials 4 vials HRP Diluent Red 1 x 12ml 1 x 23ml Stop Reagent Black 1 x 11ml 2 x 11ml Streptavidin-HRP 2 x 5µl 4 x 5µl -
Research areas
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Relevance
CD130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. -
Cellular localization
Cell membrane; single-pass type I membrane protein and secreted -
Alternative names
- CD130 antigen
- CDw130
- gp130
see all -
Database links
- Entrez Gene: 3572 Human
- SwissProt: P40189 Human
Images
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Typical Standard Curve
Representative Standard Curve using ab46135