• Product name

  Human C9 peptide
  See all C9 proteins and peptides

• Purity

  70 - 90% by HPLC.
  
  

• Animal free

  No

• Nature

  Synthetic

• • Species

    Human

• Alternative names

  • ARMD15
  • C9
  • C9 deficiency

  • C9 deficiency with dermatomyositis
  • C9D
  • CO9_HUMAN
  • Complement component 9
  • Complement component 9 deficiency
  • Complement component C9
  • Complement component C9b

  see all

• Function

  Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.

• Tissue specificity

  Plasma.

• Involvement in disease

  Defects in C9 are a cause of complement component 9 deficiency (C9D) [MIM:613825]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.

• Sequence similarities

  Belongs to the complement C6/C7/C8/C9 family.
  Contains 1 EGF-like domain.
  Contains 1 LDL-receptor class A domain.
  Contains 1 MACPF domain.
  Contains 1 TSP type-1 domain.

• Post-translational
  modifications

  Thrombin cleaves factor C9 to produce C9a and C9b.
  Phosphorylation sites are present in the extracelllular medium.

• Cellular localization

  Secreted. Cell membrane. Secreted as soluble monomer. Oligomerizes at target membranes, forming a pre-pore. A conformation change then leads to the formation of a 100 Angstrom diameter pore.

• Target information above from: UniProt accession P02748 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt